基本信息
姓名：李翡翡
电子邮箱：liffei@nwnu.edu.cn
办公地址：新校区实验综合楼B216
教育和工作经历
2019.7-至今，校聘副教授，西北师范大学生命科学学院
2016.9-2019.6，博士，中国科学院大学&中科院近代物理研究所，生物物理专业
2013.9-2016.6，硕士，中国科学院大学&中科院近代物理研究所，生物工程专业
2009.9-2013.6，学士，西北师范大学生命科学学院，生物科学专业
研究方向
肿瘤细胞生物学
近五年代表性成果
Li FF#, Li ZH#, Jin XD, Liu Y, Zhang PC, Li P, Shen ZY, Wu AG, Chen WQ*, Li Q*. Ultra-small gadolinium oxide nanocrystal sensitization of non-small-cell lung cancer cells toward X-ray irradiation by promoting cytostatic autophagy [J]. International journal of nanomedicine, 2019, 14: 2415-2431.
Li FF, Li ZH, Jin XD, Liu Y, Li P, Shen ZY, Wu AG, Zheng XG, Chen WQ*, Li Q*. Radiosensitizing Effect of Gadolinium Oxide Nanocrystals in NSCLC Cells under Carbon Ion Irradiation[J]. Nanoscale Research Letters,2019, 14(1): 328.
Li FF, Zheng XG, Liu Y, Li P, Liu X, Ye F, Zhao T, Wu Q, Jin XD*, Li Q*. Different Roles of CHOP and JNK in Mediating Radiation-Induced Autophagy and Apoptosis in Breast Cancer Cells. Radiation research 2016, 185 (5): 539-48.
李翡翡，李子厚，金晓东，吴爱国，陈卫强*，李强*。氧化钆纳米粒子对A549肺癌细胞的辐射增敏效应研究[J]. 原子核物理评论，2019, 36(3):359-364.
Li FF, Jin XD, Li Qiang. CHOP and JNK mediate radiation-induced Apoptosis and Autophagy via unfolded protein response in Breast Cancer Cells.（15thAOCMP，oral presentation）
Li FF, Jin XD, Liu Y, Zhang PC, Chen WQ, Li Q. The Effect of Gadolinium-based Nanoparticles on Human Lung Adenocarcinoma A549 Cells under X-ray and Carbon ion irradiations. (64th Annual Meeting of the Radiation Research Society, poster report)
Niu PH, Li FF, Liang XJ, etal. A porous polyaniline nanotube sorbent for solid-phase extraction of the fluorescent reaction product of reactive oxygen species in cells, and its determination by HPLC. Microchimica Acta 2018, 185(10): 468.
Ma JL, Li FF, Li Q, etal. Naked-eye and ratiometric fluorescence probe for fast and sensitive detection of hydrogen sulfide and its application in bioimaging. New journal of chemistry 2018, New J. Chem., 2018, 42, 19272.
Jin XD, Li FF, Liu BT, etal. Different mitochondrial fragmentation after irradiation with X-rays and carbon ions in HeLa cells and its influence on cellular apoptosis. Biochemical and Biophysical Research Communications 2018, 500(4):958-965.
Jin XD, Li FF, Zheng XG, etal. Carbon ions induce autophagy effectively through stimulating the unfolded protein response and subsequent inhibiting Akt phosphorylation in tumor cells. Scientific Reports 2015, 5: 13815.
李锦，李翡翡，李强，郭勇. 罗丹明B在次氯酸检测中的应用及其机理研究，西北师范大学学报（自然科学版）,2017,53 (5):57-63.
Liu Y, Zhang PC, Li FF, etal. Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells. Theranostics 2018, 8(7):1824-1849.
Jin X, Zheng XG, Li FF, etal. Fragmentation level determines mitochondrial damage response and subsequently the fate of cancer cells exposed to carbon ions. Radiother Oncol 2018, 129(1): 75-83.
Zheng XG, Jin XD, Li FF, etal. Inhibiting autophagy with chloroquine enhances the anti-tumor effect of high-LET carbon ions via ER stress-related apoptosis. Medical Oncology 2017, 34(2):25.
Yu H, Cao LY, Li FF, etal. The antioxidant mechanism of nitroxide TEMPO: scavenging with glutathionyl radicals. Rsc Adv 2015, 5(78):63655-63661.
近五年承担研究课题
2019.7-2022.12 西北师范大学生命科学学院“引进人才项目”, CRIP2调控非小细胞肺癌辐射抗性的分子机制探究
2020.1-2022.12西北师范大学校青年教师科研能力提升计划“骨干项目”, 基于蛋白组学的氧化钆纳米材料放疗增敏的分子机制探究
教学工作情况
承担课程：细胞生物学、细胞工程课程设计（本科生）；生命科学前沿进展（研究生）
获奖情况
2017-2018年度中国科学院大学“三好学生”；
兰州教育基地第四届“科兰印象”研究生摄影比赛优秀奖；
中国科学院近代物理研究所第十四届科学公众日“优秀志愿者”等