基本信息
姓 名:朱新亮
职 称:副教授(硕士生导师)
电子邮箱:xzhuaf@nwnu.edu.cn
办公地址:知行校区实验综合大楼B616
教育和工作经历
2023--至今,副教授、硕士生导师,西北师范大学生命科学学院
2018-2022,讲师,西北师范大学生命科学学院
2013-2017,博士研究生,香港科技大学-生命科学部
2009-2013,本科生,西安交通大学-生命科学与技术学院
研究方向
以代谢组学与蛋白质组学为手段的药理毒理分析
近五年代表性成果
1. Han, S., Ren, Y., He, W., Liu, H., Zhi, Z., Zhu, X., ... & Shao, Y. (2018). ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma. Nature communications, 9(1), 28.
2. Zhu X, Zhang S, Li X, et al. Integrative analysis of high temperature-induced transcriptome and metabolome alterations in the leaves of five raspberry (Rubus ideaus L.) cultivars[J]. Environmental and Experimental Botany, 2022, 203: 105038.
3. Zhu X, An W, Li X, et al. Anti-inflammatory effects of Scutellaria baicalensis water extract in LPS-induced THP-1 Macrophages through metabolomics study[J]. Arabian Journal of Chemistry, 2023, 16(3): 104507.
4. Zhu X L, Du H, Wang L L, et al. Integrative Proteome Analysis Revels 3-Hydroxybutyrate Exerts Neuroprotective Effect by Influencing Chromatin Bivalency[J]. International Journal of Molecular Sciences, 2023, 24(1): 868.
5. Zhu, X., Yu, F., Yang, Z., Liu, S., Dai, C., Lu, X., ... & Li, N. (2016). In planta chemical cross‐linking and mass spectrometry analysis of protein structure and interaction in Arabidopsis. Proteomics, 16(13), 1915-1927.
6. Zhu X, Wang X, Zhang S, et al. Metabolomic Investigation of Synergistic Mechanism for Fangfeng Extract Preventing LPS Induced Neuroinflammation in BV-2 Microglia Cells[J]. Applied Sciences, 2021, 11(17): 8155.
7. Wang X, Zhu X#, Li X, et al. Transcriptomic and metabolomic analyses provide insights into the attenuation of neuroinflammation by nervonic acid in MPTP-stimulated PD model mice[J]. Food & Function, 2023, 14(1): 277-291.
8. Li X, Wang X, Li Z, et al*. A Metabolomic Study of the Analgesic Effect of Lappaconitine Hydrobromide (LAH) on Inflammatory Pain[J]. Metabolites, 2022, 12(10): 923.
9. Zhang S, Liu Z, Li X, et al*. Comparative Study of Three Raspberry Cultivar (Rubus idaeus L.) Leaves Metabolites: Metabolome Profiling and Antioxidant Activities[J]. Applied Sciences, 2022, 12(3): 990.
10. Wang, X., Li, Z., Li, X., Liu, X., Cao, F., Zhu, X.*, & Zhang, J. (2023). Integrated metabolomics and transcriptomics reveal the neuroprotective effect of nervonic acid on LPS-induced AD model mice. Biochemical Pharmacology, 115411.
11. Hu E, Du H, Zhu X, et al. Beta-hydroxybutyrate promotes the expression of BDNF in hippocampal neurons under adequate glucose supply[J]. Neuroscience, 2018, 386: 315-325.
12. Ran, G., Tan, D., Dai, W., Zhu, X., Zhao, J., Ma, Q., & Lu, X. (2017). Immobilization of alkaline polygalacturonate lyase from Bacillus subtilis on the surface of bacterial polyhydroxyalkanoate nano-granules. Applied microbiology and biotechnology, 101, 3247-3258.
13. Tan, D., Zhao, J. P., Ran, G. Q., Zhu, X. L., Ding, Y., & Lu, X. Y. (2019). Highly efficient biocatalytic synthesis of l-DOPA using in situ immobilized V errucomicrobium spinosum tyrosinase on polyhydroxyalkanoate nano-granules. Applied microbiology and biotechnology, 103, 5663-5678.
14. Lu, X. Y., Li, M. C., Zhu, X. L., Fan, F., Wang, L. L., & Ma, J. G. (2014). Microbial synthesized biodegradable PHBHHxPEG hybrid copolymer as an efficient intracellular delivery nanocarrier for kinase inhibitor. BMC biotechnology, 14(1), 1-10.
*为通讯作者,#为共同一作
近五年承担研究课题
2021-2023,主持,甘肃省科技基金计划项目(项目编号:21JR7RA113)
2019-2021,主持,甘肃省高等学校创新能力提升项目(项目编号:2019A-017)
2020-2022,主持,西北师范大学青年教师科研能力提升计划项目(项目编号:NWNU-LKQN2020-13)
教学工作情况
主要承担课程:生物化学、生物信息学、生物信息学与实践(研究生)等。
获奖情况
西北师范大学生命科学学院2022年青年教师教学比赛 二等奖(2022年)
西北师范大学生命科学学院2021年青年教师教学比赛 二等奖(2021年)
西北师范大学第五十九届联合编队教育实习优秀教师(2019年)
西北师范大学首届教师教学创新大赛获奖教师(团队)(2021)
关于招生
招生方向:天然活性物质生物化学(生物化学与分子生物学学硕)。
欢迎具有生物化学、分子生物学、生物信息学等专业背景的考生报考研究生。