智康康

时间:2023-06-29浏览:1927设置

基本信息

姓名:智康康

电子邮箱:sqyjktwzkk@163.com

办公地址:知行校区(新校区)开物楼

教育和工作经历

2022.10-     西北师范大学生命科学学院制药工程系校聘副教授/硕导(第一层次引进)

2019.07-2022.09 西北农林科技大学食品科学与工程学院 食品安全与天然产物功能讲师/硕导

2015.09-2019.07 哈尔滨工业大学 化工与化学学院 化学工程与技术 博士

2012.09-2015.07 兰州理工大学 生命科学与工程学院 微生物与生化药学 硕士

2008.09-2012.07 兰州理工大学 生命科学与工程学院 制药工程 学士

研究方向

1. 生物活性/超分子自组装天然产物的发掘开发及应用;2. 基于多糖的自组装/纳米生物基质的发掘开发及应用;3. 农副产品精深加工及品质评价。

近五年代表性成果

学术论文

截止目前发表第一作者/通讯作者学术论文18篇,其中SCI收录16篇,中科院论文7篇,单篇IF10.02篇;非一作/通讯学术论文7篇。以下列出5发表的学术论文:

1. Zhi, K. K., Wang, J., Yang, X., & Zhao, H. (2020). Self-assembled Small Molecule Natural Product Gel for Drug Delivery: A Breakthrough in New Application of Small Molecule Natural Products. Acta Pharmaceutica Sinica B. 10(5), 913-927.IF=11.4131,外封面文章)

2. Du, Y., Chu, J., Wang, R., Zhang, C*., Zhang, J., & Zhi, K. K*. (2023). Efficient encapsulation of fat-soluble food-derived biofunctional substances (curcumin as an example) in dual-modified starch-based nanoparticles containing large conjugated systems. International Journal of Biological Macromolecules, 242, 125078. IF= 8.0251区)

3. Wang, R., Qin, X., Du, Y., Shan, Z., Shi, C., Huang, K., Wang, J.* & Zhi, K. K*. (2022). Dual-modified starch nanoparticles containing aromatic systems with highly efficient encapsulation of curcumin and their antibacterial applications. Food Research International, 162, 111926. IF= 7.4251区)

4. Zhi, K. K., Wang, R., Wei, J., Shan, Z., Shi, C., & Xia, X. (2021). Self-assembled micelles of dual-modified starch via hydroxypropylation and subsequent debranching with improved solubility and stability of curcumin. Food Hydrocolloids, 118, 106809.IF=11.5041区)

5. Zhi, K. K., Yang, H., Shan, Z., Huang, K., Zhang, M., & Xia, X. (2021). Dual-modified starch nanospheres encapsulated with curcumin by self-assembly: structure, physicochemical properties and anti-inflammatory activity. International Journal of Biological Macromolecules. 191, 305-314. IF= 8.0251区)

6. Zhi, K. K., Zhao, H., Yang, X., Zhang, H., Wang, J., Wang, J., & Regenstein, J. M. (2018). Natural product gelators and a general method for obtaining them from organisms. Nanoscale, 10(8), 3639-3643.IF=7.2331区)

7. Zhi, K. K., Ying Sun, Haitian Zhao, Changmei Zhang, Haisheng Peng, Xin Yang (2020). Self-assembled supramolecular material derived from traditional Chinese medicine: injectable self-assembled natural product gel for drug delivery with biological activity. Materials Today Communications. 23, 101149. IF=3.3833区)

8. Zhi, K. K., Zhao, H., Yang, X., Zhang, H., Wang, J., & Wang, Z. (2018). Solvent-induced Gel Formation Hypothesis for Natural Product Gelators with Polycyclic Structures. ChemPlusChem, 83(8), 797-803.IF= 3.2053区)

9. Zhi, K. K., Yang, X. (2019). Natural Product Gels and Their Gelators(中文). Progress in Chemistry. 31(9), 1314-1328. IF=1.0133区)

10. Hyeonjin Janga#, Zhi, K. K.#, Jiacheng Wang#, Haitian Zhao, Bin Li, Xin Yang (2020). Enhanced therapeutic effect of paclitaxel with a natural polysaccharide carrier for local injection in breast cancer. International Journal of Biological Macromolecules.148, 163-172. IF= 8.0251区)

11. He, N.#, Zhi, K. K.#, Yang, X., Zhao, H., Zhang, H., Wang, J., & Wang, Z. (2018). Self-assembled fibrillar networks induced by two methods: a new unmodified natural product gel. New Journal of Chemistry, 42(17), 14170-14178.IF= 3.2013区)

12. Bai, F., Guo, D., Wang, Y., Zhang, S., Li, J., Zhi, K. K., Chao Shi & Xia, X. (2022). The combined bactericidal effect of nisin and thymoquinone against Listeria monocytogenes in Tryptone Soy Broth and sterilized milk. Food Control, 135, 108771. IF= 6.6523区)

13. Wang, J., Zhao, H., Zhi, K. K., & Yang, X. (2020). Exploration of the natural active small-molecule drug-loading process and highly efficient synergistic antitumor efficacy. ACS Applied Materials & Interfaces, 12(6), 6827-6839. IF= 10.3832区)

14. Yang, X., Ma, C., Chen, Z., Liu, J., Liu, F., Xie, R., Zhao, H., Deng, G., Chen, T. Gong, N. Yao, L. Zuo, P. Zhi, K. K., Wang, J. Gao, X. Wang, J. Fan, L. & Zhou, J. (2019). Single small molecule-assembled nanoparticles mediate efficient oral drug delivery. Nano research, 12(10), 2468. IF= 8.8971区)

专利:

第二申请人申请专利6项,授权3项;第三申请人申请专利4项,授权1项。以下仅列出授权专利:

1. 《圆锥山蚂蝗枝叶中分离的化合物及其制备方法和用途》,专利号:2014101597166,授权

2. 《一种制备葡萄糖双功能单体磁性分子印迹聚合物的方法》,专利号:2015108113341,授权

3. 《一种天然产物凝胶质的制备方法》,专利号:201810013617.5,授权

4. 《一种紫杉醇负载红松松塔多糖-A凝胶及其制备方法与应用》,专利号:2 019108020468,授权

学术会议:

1. 201805月 哈尔滨工业大学化工与化学学院第八届博士生学术论坛,哈尔滨,黑龙江,中国(Speaker,金奖)。

2. 201806The 92nd American Chemical Society (ACS) Colloid & Surface Science Symposium, State College, Pennsylvania, USA. (Poster).

3. 201911月 第五届《药学学报》药学前沿论坛暨第四届表观遗传与生物医药研发国际学术大会,广州,广东,中国Speaker,青年论坛优秀论文奖)。

4. 2021042021年行思青年论坛第3期,杨凌,陕西,中国Speaker

5. 2021062021年空军军医大学药物前沿创新高峰论坛,西安,陕西,中国。

6. 2022122022 生物与制药前沿学术研讨会,兰州,甘肃,中国Speaker

获奖情况

指导学生团队荣获2021年全国大学生生命科学竞赛国家级三等奖1项,省级二等奖1项,省级三等奖1)、校级优秀毕业生指导教师(2022年)、优秀本科毕业论文指导教师(2022年)、2021年度先进个人、优秀班主任(2021年)、研究生国家奖学金等。


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